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Expression data from G1E erythroid cells expressing GATA1 mutants

ABSTRACT: Missense mutations in transcription factor GATA1 underlie several distinct forms of anemia and thrombocytopenia. Clinical severity depends on the site and type of substitution, and distinct substiutions of the same residue produce disparate phenotypes. To investigate the effect of GATA1 missense mutations on erythroid differentiation we expressed conditionally activated wild type or mutant versions of GATA1 in GATA1-null G1E cells. We used gene expression microarrays to explore how GATA1 missense mutations affect erythroid transcription programs.

ORGANISM(S): Mus musculus

PROVIDER: GSE43356 | GEO | 2013/03/04

SECONDARY ACCESSION(S): PRJNA185504

REPOSITORIES: GEO

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Expression data from G1E erythroid cells expressing GATA1 mutants

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