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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

ABSTRACT: We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted total mRNA from parental cells and resistant cell lines. We compared their expression by carried out Affymetrix Huex 1.0 ST expression array.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45648 | GEO | 2014/12/17

SECONDARY ACCESSION(S): PRJNA195561

REPOSITORIES: GEO

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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

Project description:We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted total mRNA from parental cells and resistant cell lines. We compared their expression by carried out Affymetrix Huex 1.0 ST expression array. Two paired parental/derived cell lines were screened as per the summary above. BRAF inhibitory resistant cells had gene expression compared to the parental cell lines.

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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

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