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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

ABSTRACT: We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted total mRNA from parental cells and resistant cell lines. We compared their expression by carried out Affymetrix Huex 1.0 ST expression array. Two paired parental/derived cell lines were screened as per the summary above. BRAF inhibitory resistant cells had gene expression compared to the parental cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Hoon Dave

PROVIDER: S-ECPF-GEOD-45648 | biostudies-other |

REPOSITORIES: biostudies-other

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Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-12-17 | E-GEOD-45649 | biostudies-arrayexpress

Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]

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Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas.

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