Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide analysis of BRCA1 and PALB2

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45715 | GEO | 2013/09/30

SECONDARY ACCESSION(S): PRJNA195926

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome-wide analysis of BRCA1 and PALB2

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-09-30 | E-GEOD-45715 | biostudies-arrayexpress

Genome-wide analysis of BRCA1 and PALB2 [RA stimulation]

Project description:Breast and ovarian cancer susceptibility genes, BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian development. While these genes are essential for growth during early developmental programs, inactivation later in adulthood leads to increased growth and formation of tumors, leading to their designation as tumor suppressors. We performed genome-wide analysis assessing their chromatin residence and gene expression responsiveness using high throughput sequencing in breast epithelial cells. These experiments revealed a critical role for BRCA1 and PALB2 in transcriptional responsiveness to NF-kB, a crucial mediator of growth and inflammatory response during development and cancer. Importantly, we also uncovered a vital role for these proteins in response to retinoic acid (RA), a growth inhibitory signal in breast cancer cells, which may constitute the basis for their tumor suppressor activity. MCF-7 cells were infected with PALB2, BRCA1 and non targeting (SCR) shRNAs. After puromycin selection, cells were stimulated with 10microM Retinoic Acid (RA) for 24 hours

| S-ECPF-GEOD-45714 | biostudies-other

Genome-wide analysis of the Integrator complex

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-09-09 | E-GEOD-58255 | biostudies-arrayexpress

Genome-wide chromatin analysis of Ewing sarcoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-30 | E-GEOD-61953 | biostudies-arrayexpress

Genome-wide analysis of BRCA1 and PALB2 [TNF-alpha stimulation]

Project description:Breast and ovarian cancer susceptibility genes, BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian development. While these genes are essential for growth during early developmental programs, inactivation later in adulthood leads to increased growth and formation of tumors, leading to their designation as tumor suppressors. We performed genome-wide analysis assessing their chromatin residence and gene expression responsiveness using high throughput sequencing in breast epithelial cells. These experiments revealed a critical role for BRCA1 and PALB2 in transcriptional responsiveness to NF-kB, a crucial mediator of growth and inflammatory response during development and cancer. Importantly, we also uncovered a vital role for these proteins in response to retinoic acid (RA), a growth inhibitory signal in breast cancer cells, which may constitute the basis for their tumor suppressor activity. MCF-7 cells were infected with PALB2, BRCA1, p65/RelA and non targeting (SCR) shRNAs. After puromycin selection, cells were stimulated with 10ng/ml TNF-alpha 1 hour

| S-ECPF-GEOD-45713 | biostudies-other

Genome-wide parent-of-origin DNA methylation analysis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-28 | E-GEOD-52578 | biostudies-arrayexpress

Genome-wide analysis of stress response in mouse fibroblasts

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-11 | E-GEOD-55784 | biostudies-arrayexpress

Genome-wide analysis of liver in male and female mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-04-01 | E-GEOD-47899 | biostudies-arrayexpress

Genome-wide analysis of heritable dog osteosarcoma in 3 breeds

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series