Genomics

Dataset Information

0

Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]


ABSTRACT: A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through integrated chemical-genetic analyses, we find that a dominant transcriptional effect of blocking protein translation in cancer cells is complete inactivation of heat shock factor 1 (HSF1), a multifaceted transcriptional regulator of the heat-shock response and many other cellular processes essential for tumorigenesis. Translational flux through the ribosome reshapes the transcriptional landscape and links the fundamental anabolic processes of protein production and energy metabolism with HSF1 activity. Targeting this link deprives cancer cells of their energy and chaperone armamentarium thereby rendering the malignant phenotype unsustainable.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45852 | GEO | 2013/07/21

SECONDARY ACCESSION(S): PRJNA196591

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-07-21 | E-GEOD-45852 | biostudies-arrayexpress
2013-07-21 | GSE45851 | GEO
2013-07-21 | E-GEOD-45851 | biostudies-arrayexpress
2022-03-15 | GSE194098 | GEO
2018-07-26 | GSE117653 | GEO
2020-10-16 | GSE138959 | GEO
2012-09-20 | GSE41005 | GEO
2015-02-20 | GSE57397 | GEO
2022-01-25 | MODEL2201210001 | BioModels
2018-03-20 | GSE90716 | GEO