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Genes responsive to bisphenol A in testicular Sertoli cells

ABSTRACT: We performed global scale microarray analysis to identify detailed mechanisms by which bisphenol A (BPA) induce cell death by using an Affymetrix GeneChip system. Testicular Sertoli TTE3 cells used in the present study were derived from transgenic mice harboring a temperature-sensitive simian virus 40 large T-antigen. Cell death accompanying endoplasmic reticulum stress was observed in the cells treated with 0.2 mM BPA. Of the 22,690 probe sets analyzed, approximately 1,300 genes were down- and up-regulated by a factor of 2.0 or greater in the cells treated with BPA. Keywords: bisphenol A, gene expression, testicular Sertoli cell

ORGANISM(S): Mus musculus

PROVIDER: GSE4650 | GEO | 2006/04/13

SECONDARY ACCESSION(S): PRJNA95289

REPOSITORIES: GEO

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