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Cardiac profiling of Yap-bound chromatin in neonatal Salvador mutant mice

ABSTRACT: In this study, we identified chromatin regions bound by YAP, a major effector of the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and and tamoxifen inducible Myh6-cre/Esr1 allele, Cre activity was induced with 4 consecutive intraperitoneal (i.p.) or subcutaneous injections of tamoxifen from P7-P10.

OTHER RELATED OMICS DATASETS IN: PRJNA188669

ORGANISM(S): Mus musculus

PROVIDER: GSE46529 | GEO | 2019/09/25

REPOSITORIES: GEO

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Cardiac gene expression profiling of neonatal Salvador mutant mice

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Cardiac gene expression profiling of neonatal Salvador mutant mice

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