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IQGAP2 knockout model of hepatocellular carcinoma

ABSTRACT: Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. Results provide insights into the potential role of IQGAP2 as a liver-specific tumor suppressor.

ORGANISM(S): Mus musculus

PROVIDER: GSE46646 | GEO | 2013/12/13

SECONDARY ACCESSION(S): PRJNA201382

REPOSITORIES: GEO

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IQGAP2 knockout model of hepatocellular carcinoma

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