Proteomics

Dataset Information

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Mouse Heart SS-31 Proteome and Phosphoproteome

ABSTRACT: The heart proteome and phosphoproteome were analyzed in young (5-6-month old), old (24-month old at the start of the study), and elamipretide-treated (for 8 weeks) old mice using shotgun proteomics methods in order to assess the effects of aging on signaling and the ability of mitochondrion-targeted drug elamipretide (SS-31) to reverse age-related changes. Enhancement and suppression of phosphorylation at sites along a variety of proteins was found to occur with age. Elamipretide treatment partially restored the phosphorylation state of proteins that had increased phosphorylation with age, but did not have a large effect those that had decreased phosphorylation with age.

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Judit Villen  

LAB HEAD: Judit Villen

PROVIDER: PXD026335 | Pride | 2022-02-17

REPOSITORIES: Pride

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Action DRS
17092_q10505_mmp_mouse_heartSS31_trypsin_LFQ_1039-5.fasta Fasta
17092_q10505_mmp_mouse_heartSS31_trypsin_LFQ_1039-5.mzXML Mzxml
17092_q10505_mmp_mouse_heartSS31_trypsin_LFQ_1039-5.mzid.gz Mzid
17092_q10505_mmp_mouse_heartSS31_trypsin_LFQ_1039-5.pepXML Pepxml
17092_q10505_mmp_mouse_heartSS31_trypsin_LFQ_1039-5.raw Raw
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Publications

It has been demonstrated that elamipretide (SS-31) rescues age-related functional deficits in the heart but the full set of mechanisms behind this have yet to be determined. We investigated the hypothesis that elamipretide influences post-translational modifications to heart proteins. The S-glutathionylation and phosphorylation proteomes of mouse hearts were analyzed using shotgun proteomics to assess the effects of aging on these post-translational modifications and the ability of the mitochond  ...[more]

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