Dataset Information

Quantitative Top-Down Proteomics Analysis of Age-related Changes in Murine Hearts

ABSTRACT: Label-free quantitative top-down proteomics was performed on mitochondrial lysate isolated from the hearts of 3 young (4-month-old) and 3 old (24-25-month-old) mice.

INSTRUMENT(S): Orbitrap Exploris 240

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Kellye Sutton

LAB HEAD: Si Wu

PROVIDER: PXD051505 | Pride | 2024-10-17

REPOSITORIES: Pride

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Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics.

Ramirez-Sagredo Andrea A Sunny Anju Teresa AT Cupp-Sutton Kellye A KA Chowdhury Trishika T Zhao Zhitao Z Wu Si S Chiao Ying Ann YA

Clinical proteomics 20240930 1

<h4>Background</h4>Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and the prevalence of CVDs increases markedly with age. Due to the high energetic demand, the heart is highly sensitive to mitochondrial dysfunction. The complexity of the cardiac mitochondrial proteome hinders the development of effective strategies that target mitochondrial dysfunction in CVDs. Mammalian mitochondria are composed of over 1000 proteins, most of which can undergo post-translational modifi ...[more]

PMID: 39343872

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			Action	DRS
	Mit_Old1_T1.raw	Raw
	Mit_Old1_T1_ID.csv	Csv
	Mit_Old1_T2.raw	Raw
	Mit_Old1_T2_ID.csv	Csv
	Mit_Old2_T1.raw	Raw