Transcriptomics

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Gene expression pattern of synovial cells from inflammatory and normal areas of osteoarthritis synovial membrane


ABSTRACT: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same osteoarthritis (OA) patient. This study is the first to identify different expression pattern between two areas of the synovial membrane in the same patient. These differences concern several key pathways involved in OA pathogenesis (inflammation, cartilage metabolism, Wnt signaling and angiogenesis). This analysis also provides interesting information regarding new potent intermediates as potentiel targets for the future therapeutic.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46750 | GEO | 2013/05/20

SECONDARY ACCESSION(S): PRJNA202240

REPOSITORIES: GEO

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