Transcriptomics

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Transcriptomic analysis of mouse lung tissue exposed to multiwalled carbon nanotubes (Mitsui7)


ABSTRACT: There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary responses of multiwalled carbon nanotubes (MWCNT) to those in vitro in cultured lung epithelial cells at the global transcriptomic level. Mice were exposed via a single intratracheal instillation to 18, 54 or 162 μg of Mitsui7 and samples were collected at 24 hours post-instillation.

ORGANISM(S): Mus musculus

PROVIDER: GSE46998 | GEO | 2015/05/05

SECONDARY ACCESSION(S): PRJNA203260

REPOSITORIES: GEO

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