Methylation profiling

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Characterization of genome-methylome interactions in 22 nuclear pedigrees


ABSTRACT: In this study, we investigated the interaction between CpG methylation and genetic polymorphisms by taking the advantage of the family structure in 22 nuclear pedigrees. We have identified CpG sites that exhibit heritable methylation patterns, among which the majority are SNPs ditrectly disrupting CpG dinucleotides. We also identified 27.2% of the heritable non-SNP CpGs were associated with cis-regulatory SNPs. Additionally, we have identified hundreds of CpG clusters whose the degree of DNA methylation variation is associated with genetic polymorphism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE47614 | GEO | 2013/06/20

SECONDARY ACCESSION(S): PRJNA206616

REPOSITORIES: GEO

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