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Time series of global gene expression after trivalent influenza vaccination in humans (female cohort)

ABSTRACT: The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells before and at three time points after the administration of a trivalent influenza vaccine in human female subjects, and to relate these to the antibody response to the vaccine

ORGANISM(S): Homo sapiens

PROVIDER: GSE48023 | GEO | 2013/06/18

SECONDARY ACCESSION(S): PRJNA208721

REPOSITORIES: GEO

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Time series of global gene expression after trivalent influenza vaccination in humans (female cohort)

Project description:The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells before and at three time points after the administration of a trivalent influenza vaccine in human female subjects, and to relate these to the antibody response to the vaccine 128 healthy female human volunteers ages 19 - 41 years were recruited in the study. Whole-blood RNA samples were collected in PaxGene tubes before and at three time points after administration of a trivalent influenza vaccine. Baseline samples (before vaccination) are labeled as day 0. The three additional time points are days 1, 3, and 14 after vaccination. A total of 417 arrays, corresponding to 110 individuals, passed quality control, corresponded to individuals where at least two of the four arrays in the series were available, and corresponded to individuals who were ethnically homogeneous as determined by identity-by-state and multidimensional scaling analysis of their genotype data. That set of 417 arrays was used for analysis in the associated publication and was therefore included in this GEO upload. These are distributed as follows: Day 0: 107 Samples Day 1: 107 Samples Day 3: 105 Samples Day 14: 98 Samples

2013-06-18 | E-GEOD-48023 | biostudies-arrayexpress

Time series of global gene expression after trivalent influenza vaccination in humans (male cohort)

2013-06-18 | GSE48018 | GEO

Time series of global gene expression after trivalent influenza vaccination in humans (male cohort)

Project description:The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells before and at three time points after the administration of a trivalent influenza vaccine in human male subjects, and to relate these to the antibody response to the vaccine. The antibody titer data for these subjects is provided as a supplemental file. 119 healthy male human volunteers ages 19 - 41 years were recruited in the study. Whole-blood RNA samples were collected in PaxGene tubes before and at three time points after administration of a trivalent influenza vaccine. Baseline samples (before vaccination) are labeled as day 0. The three additional time points are days 1, 3, and 14 after vaccination. A total of 431 arrays, corresponding to 116 individuals, passed quality control and are included in this data set. These are distributed as follows: Day 0: 111 Samples Day 1: 110 Samples Day 3: 101 Samples Day 14: 109 Samples

2013-06-18 | E-GEOD-48018 | biostudies-arrayexpress

Influenza peptide reactivity within a cohort of age-stratified individuals pre and post vaccination with the 2008/2009 trivalent influenza vaccine

2013-05-01 | GSE43446 | GEO

Influenza peptide reactivity within a cohort of age-stratified individuals pre and post vaccination with the 2008/2009 trivalent influenza vaccine

Project description:The aim of the study was to test the hypothesis that peptide array reactivity will reveal patterns that can be associated with poor or effective neutralization response to seasonal influenza vaccine We diluted patient sera 1:80 and incubated dilutions on a streptavidin-coated glass surface that was printed with biotinylated peptides derived from seasonal strains of influenza hemagglutinin included in the 2008/2009 trivalent influenza vaccine In this study, serum from 76 study participants, subsetted into young (?30 years old) and elderly (?60 years old) categories were profiled for IgG/IgM antibody reactivity to influenza hemagglutinin peptudes. Using multivariate linear regression and correcting for multiple hypothesis testing by cross-validation, ee found that patterns of peptide reactivity associated with a poor or effective neutralization response to H1N1 and B strains of influenza.

2013-05-01 | E-GEOD-43446 | biostudies-arrayexpress

Time series of global gene expression after trivalent influenza vaccination in humans

Project description:Time series of global gene expression after trivalent influenza vaccination in humans

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Time series of global gene expression after trivalent influenza vaccination in humans

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-06-18 | GSE48024 | GEO

Systems biology of immunity to MF59-adjuvanted versus non-adjuvanted trivalent seasonal influenza vaccines in early childhood

Project description:Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in ninety 14-24 month old healthy children.

2016-01-31 | GSE74975 | GEO

Time series of global gene expression after trivalent influenza vaccination in humans

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-18 | E-GEOD-48024 | biostudies-arrayexpress

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

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