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Time series of global gene expression after trivalent influenza vaccination in humans

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE48024 | GEO | 2013/06/18

SECONDARY ACCESSION(S): PRJNA208719

REPOSITORIES: GEO

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Time series of global gene expression after trivalent influenza vaccination in humans

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Project description:The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells before and at three time points after the administration of a trivalent influenza vaccine in human male subjects, and to relate these to the antibody response to the vaccine. The antibody titer data for these subjects is provided as a supplemental file. 119 healthy male human volunteers ages 19 - 41 years were recruited in the study. Whole-blood RNA samples were collected in PaxGene tubes before and at three time points after administration of a trivalent influenza vaccine. Baseline samples (before vaccination) are labeled as day 0. The three additional time points are days 1, 3, and 14 after vaccination. A total of 431 arrays, corresponding to 116 individuals, passed quality control and are included in this data set. These are distributed as follows: Day 0: 111 Samples Day 1: 110 Samples Day 3: 101 Samples Day 14: 109 Samples

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