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Time series of global gene expression after trivalent influenza vaccination in humans

ABSTRACT: Time series of global gene expression after trivalent influenza vaccination in humans

PROVIDER: PRJNA208719 | ENA |

REPOSITORIES: ENA

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Time series of global gene expression after trivalent influenza vaccination in humans (female cohort)

Project description:The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells before and at three time points after the administration of a trivalent influenza vaccine in human female subjects, and to relate these to the antibody response to the vaccine 128 healthy female human volunteers ages 19 - 41 years were recruited in the study. Whole-blood RNA samples were collected in PaxGene tubes before and at three time points after administration of a trivalent influenza vaccine. Baseline samples (before vaccination) are labeled as day 0. The three additional time points are days 1, 3, and 14 after vaccination. A total of 417 arrays, corresponding to 110 individuals, passed quality control, corresponded to individuals where at least two of the four arrays in the series were available, and corresponded to individuals who were ethnically homogeneous as determined by identity-by-state and multidimensional scaling analysis of their genotype data. That set of 417 arrays was used for analysis in the associated publication and was therefore included in this GEO upload. These are distributed as follows: Day 0: 107 Samples Day 1: 107 Samples Day 3: 105 Samples Day 14: 98 Samples

2013-06-18 | E-GEOD-48023 | biostudies-arrayexpress

Time series of global gene expression after trivalent influenza vaccination in humans (male cohort)

Project description:The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells before and at three time points after the administration of a trivalent influenza vaccine in human male subjects, and to relate these to the antibody response to the vaccine. The antibody titer data for these subjects is provided as a supplemental file. 119 healthy male human volunteers ages 19 - 41 years were recruited in the study. Whole-blood RNA samples were collected in PaxGene tubes before and at three time points after administration of a trivalent influenza vaccine. Baseline samples (before vaccination) are labeled as day 0. The three additional time points are days 1, 3, and 14 after vaccination. A total of 431 arrays, corresponding to 116 individuals, passed quality control and are included in this data set. These are distributed as follows: Day 0: 111 Samples Day 1: 110 Samples Day 3: 101 Samples Day 14: 109 Samples

2013-06-18 | E-GEOD-48018 | biostudies-arrayexpress

Time series of global gene expression after trivalent influenza vaccination in humans (female cohort)

2013-06-18 | GSE48023 | GEO

Time series of global gene expression after trivalent influenza vaccination in humans (male cohort)

2013-06-18 | GSE48018 | GEO

Influenza peptide reactivity within a cohort of age-stratified individuals pre and post vaccination with the 2008/2009 trivalent influenza vaccine

Project description:The aim of the study was to test the hypothesis that peptide array reactivity will reveal patterns that can be associated with poor or effective neutralization response to seasonal influenza vaccine We diluted patient sera 1:80 and incubated dilutions on a streptavidin-coated glass surface that was printed with biotinylated peptides derived from seasonal strains of influenza hemagglutinin included in the 2008/2009 trivalent influenza vaccine

2013-05-01 | GSE43446 | GEO

Systems biology of vaccination for seasonal influenza in humans

Project description:Systems biology of vaccination for seasonal influenza in humans

| PRJNA141363 | ENA

Time Course of Young Adults Vaccinated with Influenza LAIV Vaccine during 2008/09 Flu Season

2011-07-10 | GSE29615 | GEO

Time Course of Young Adults Vaccinated with Influenza TIV Vaccine during 2007/08 Flu Season

2011-07-10 | GSE29614 | GEO

Time Course of Young Adults Vaccinated with Influenza TIV Vaccine during 2008/09 Flu Season

2011-07-10 | GSE29617 | GEO

Time Course of Young Adults Vaccinated with Influenza LAIV Vaccine during 2008/09 Flu Season

Project description:Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivated influenza (TIV) and live attenuated influenza (LAIV) vaccination in humans, and to identify early gene signatures that predict the magnitude of the antibody responses to influenza vaccination. During the 2008 influenza season, healthy adults were vaccinated with LAIV (28 vaccinees), and blood samples isolated at days 0, 3, 7 post-vaccination. Microarrays were performed using total RNA extracted from the peripheral blood mononuclear cells of vaccinees.

2011-07-10 | E-GEOD-29615 | biostudies-arrayexpress

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