Transcriptomics

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Maternal obesity affects fetal neurodevelopmental and metabolic gene expression


ABSTRACT: To investigate fetal gene expression in obese compared to lean women in the second trimester, by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from obese cases and lean controls revealed differential expression of 205 genes. Functional analysis of differentially expressed genes suggested down-regulation of apoptosis in fetuses of obese women, particularly within nervous system pathways involving the cerebral cortex, and activation of pro-estrogenic, pro-inflammatory transcriptional regulators.

ORGANISM(S): Homo sapiens

PROVIDER: GSE48521 | GEO | 2013/07/04

SECONDARY ACCESSION(S): PRJNA210420

REPOSITORIES: GEO

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