Transcriptomics

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Gene expression of non-apoptotic pancreatic acinar cell death with autophagy


ABSTRACT: Serine protease inhibitor Kazal type 3 (Spink3) is a trypsin inhibitor in the pancreas. Spink3-/- pancreatic acinar cells are dead with excessive autophagy at birth (p0.5). To prove the role of nonapoptotic cell death with autophagy, we generated by transgenic technology the pancreas of Spink3-/-;XKI/+ mice contained both normal and dying acinar cells with autophagy. In this new mouse model, chronic inflammation occurred in the pancreas, indicating that some signals from nonapoptotic dead cell induce chronic inflammation in the pancreas.

ORGANISM(S): Mus musculus

PROVIDER: GSE48946 | GEO | 2016/07/16

SECONDARY ACCESSION(S): PRJNA212376

REPOSITORIES: GEO

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