Transcriptomics

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Human Bone Marrow Stromal Cells cultured on 3D nanofiber scaffolds or 2D films


ABSTRACT: Microarray analysis was used to evaluate expression differences from a single donor human bone marrow stromal cells (hBMSCs) as a function of varied polymer-based tissue engineering scaffolds. These scaffolds include polycaprolactone (PCL) nanofibers (PCL_NF), films (PCL_SC), poly D,L-lactic acid (PDLLA) nanofibers (PDLLA_NF), films (PDLLA_SC), tissue culture polystyrene (TCPS) and TCPS with osteogenic supplements (TCPS_OS). The results revealed that scaffold structure was able to significantly affect gene expression, with nanofiber scaffolds inducing similar gene expression patterns to hBMCSs cultured with osteogenic media.

ORGANISM(S): Homo sapiens

PROVIDER: GSE50744 | GEO | 2013/11/01

SECONDARY ACCESSION(S): PRJNA218628

REPOSITORIES: GEO

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