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Attenuated sensing of SHH underlies adaptive evolution of bovine limbs


ABSTRACT: Artiodactyls display skeletal adaptations for cursorial (running) locomotion. In these animals, the distal limb skeleton is symmetric, which facilitates walking on the tips of the two central digits, while lateral digits are reduced or lost. We have identified that one primary molecular alteration during the formation of the bovine limb is that, in contrast to mouse, the posterior limb bud mesenchyme does not upregulate Ptch1 expression in response to SHH. We have tracked down this dissimilarity to a cis-regulatory SHH-responsive element that is functionally altered in bovine and established a causal link between lack of upregulation of Ptch1 and acquisition of a symmetric distal autopod.

ORGANISM(S): Mus musculus

PROVIDER: GSE52988 | GEO | 2014/06/19

SECONDARY ACCESSION(S): PRJNA230633

REPOSITORIES: GEO

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