Transcriptomics

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Expression data from fracture hematoma tissue of young and old rats after 3days of rigid or semi-rigid fixation of an osteotomy


ABSTRACT: The long-term healing outcome of bone regeneration is known to depend not only on mechanical stability, but also on age and, more importantly, on the overlap of both parameters. Although especially the early healing period determines the healing outcome, it so far remains unclear which factor - mechanical loading or age - dominates this phase and how these factors interact on the molecular level in the early fracture hematoma. We used microarrays to detail the global programme of gene expression underlying the influence of fixation stability in young and old rats and identified distinct classes of regulated genes during this process.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE53256 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA231357

REPOSITORIES: GEO

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