Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Zrf1 is required to establish and maintain neural progenitor identity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE53542 | GEO | 2013/12/21

SECONDARY ACCESSION(S): PRJNA232347

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Zrf1 is required to establish and maintain neural progenitor identity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-21 | E-GEOD-53542 | biostudies-arrayexpress

Zrf1 is required to establish and maintain neural progenitor identity.

Project description:The molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs) are largely unknown. Recently, we reported that the Zuotin-related factor 1 (Zrf1) is necessary for chromatin displacement of the Polycomb-repressive complex 1 (PRC1). We found that Zrf1 is required for NPC specification from ESCs and that it promotes the expression of NPC markers, including the key regulator Pax6. Moreover, Zrf1 is essential to establish and maintain Wnt ligand expression levels, which are necessary for NPC self-renewal. Reactivation of proper Wnt signaling in Zrf1-depleted NPCs restores Pax6 expression and the self-renewal capacity. ESC-derived NPCs in vitro resemble most of the characteristics of the self-renewing NPCs located in the developing embryonic cortex, which are termed radial glial cells (RGCs). Depletion of Zrf1 in vivo impairs the expression of key self-renewal regulators and Wnt ligand genes in RGCs. Thus, we demonstrate that Zrf1 plays an essential role in NPC generation and maintenance.

| S-EPMC3909791 | biostudies-literature

Zrf1 is required to establish and maintain neural progenitor identity (mRNA array)

Project description:Our work aims to characterize the role of Zrf1 in the generation and maintenance of neural progenitor cells (NPCs) Gene expression profile of shCtrl and shZrf1 cells during generation of RGC-like NPC from ESC at day 6 of neural induction. Cells were grown according to this protocol: Bibel et al, Nat Prot., 2007

2013-12-21 | E-GEOD-53541 | biostudies-arrayexpress

Zrf1 is required to establish and maintain neural progenitor identity (ChIP-Seq)

Project description:We report ChIP-seq data for Zrf1 and Ring1B occupancy in NPC Examination and comparison of DNA binding profile of Zrf1 and Ring1B in NPC

2013-12-21 | E-GEOD-53540 | biostudies-arrayexpress

Zrf1 is required to establish and maintain neural progenitor identity (mRNA array)

Project description:Our work aims to characterize the role of Zrf1 in the generation and maintenance of neural progenitor cells (NPCs)

2013-12-21 | GSE53541 | GEO

Zrf1 is required to establish and maintain neural progenitor identity (ChIP-Seq)

Project description:We report ChIP-seq data for Zrf1 and Ring1B occupancy in NPC

2013-12-21 | GSE53540 | GEO

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-02-13 | E-GEOD-44288 | biostudies-arrayexpress

Tcf1 and Lef1 establish CD8+ T cell identity via their intrinsic histone deacetylase activity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-12 | E-GEOD-73240 | biostudies-arrayexpress

Cell autonomous expression of Bcl6 is required to maintain lineage identity of mouse CCR6+ ILC3s

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-28 | GSE220438 | GEO

Activation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-20 | E-GEOD-42454 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data