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Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55007 | GEO | 2014/06/02

SECONDARY ACCESSION(S): PRJNA238234

REPOSITORIES: GEO

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Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-02 | E-GEOD-55007 | biostudies-arrayexpress

Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program.

Project description:The pioneering factor FOXA1 opens chromatin to facilitate androgen receptor (AR) binding to prostate-specific genes. How FOXA1 controls the AR cistrome, however, is incompletely understood. Here we show that AR directly binds chromatin through the androgen response elements (AREs). FOXA1 is not required for AR-chromatin interaction, but instrumental in recruiting AR to low-affinity half-AREs by opening local chromatin around adjacent FKHD sites. Too much FOXA1 creates excessive open chromatin regions, which serve as reservoirs that retain AR via abundant half-AREs, thereby reducing its availability for specific sites. FOXA1 downregulation, by contrast, relinquishes AR to permissively bind AREs across the genome, resulting in substantial AR-binding events and AR target gene expression even in the absence of androgen. Taken together, our data illustrate the mechanistic details by which cooperativity and equilibrium with FOXA1 define AR cistrome and reveal a previously unknown function of FOXA1 in inhibiting AR signalling and castration-resistant prostate cancer growth.

| S-EPMC4088269 | biostudies-literature

Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program [array]

Project description:Previous studies have shown that FOXA1 defines prostatic AR binding events, the underlying mechanisms of which, however, are incompletely understood. To test whether ectopic AR and FOXA1 can activate AR target genes, we performed adenoviral of LacZ, AR, FOXA1 or AR+FOXA1 proteins in DU145 cells, followed by microarray analysis of these cells.

2014-06-02 | E-GEOD-54991 | biostudies-arrayexpress

Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program [array]

Project description:Previous studies have shown that FOXA1 defines prostatic AR binding events, the underlying mechanisms of which, however, are incompletely understood.

2014-06-02 | GSE54991 | GEO

Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program

Project description:Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program

| PRJNA238234 | ENA

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

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Pioneer factor FOXA1 defines GATA2- and AR-mediated transcriptional program in prostate cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-01-11 | E-GEOD-69045 | biostudies-arrayexpress

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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Pioneer factor FOXA1 defines GATA2- and AR-mediated transcriptional program in prostate cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-01-11 | GSE69045 | GEO

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