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Mouse liver transcription profiling by array

ABSTRACT: Analysis of livers of male and female B6C3F1 mice exposed to prototype treatments from five classes of model hepatotoxicants. These hepatotoxicants include compounds that activate the peroxisome proliferator-activated receptor (PPAR), induce the inflammatory response, activate the constitutive androstane receptor (CAR), stimulate the hypoxia signal transduction pathway, and activate the aryl-hydrocarbon receptor (AHR). The results provide insights into the shared and unique pathways that are activated across these model hepatotoxicants.

ORGANISM(S): Mus musculus

PROVIDER: GSE55084 | GEO | 2014/02/21

SECONDARY ACCESSION(S): PRJNA238597

REPOSITORIES: GEO

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Mouse liver transcription profiling by array

Project description:Analysis of livers of male and female B6C3F1 mice exposed to prototype treatments from five classes of model hepatotoxicants. These hepatotoxicants include compounds that activate the peroxisome proliferator-activated receptor (PPAR), induce the inflammatory response, activate the constitutive androstane receptor (CAR), stimulate the hypoxia signal transduction pathway, and activate the aryl-hydrocarbon receptor (AHR). The results provide insights into the shared and unique pathways that are activated across these model hepatotoxicants. Exposures of mice of both sexes were initiated at 7 weeks of age. Matched vehicle controls were run concurrently with each exposure and gene expression levels in liver tissue compared between exposed and control animals.

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