Proteome and Phosphoproteome of AhR-dependent non-genomic signaling in endotoxin-activated macrophages
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ABSTRACT: Emerging studies revealed an immunomodulatory role of the Aryl hydrocarbon receptor (AhR), a receptor sensing environmental contaminants, and involved in their detoxification. Besides its function as a transcription factor, AhR can participate in non-genomic signaling through ubiquitination and phosphorylation-dependent processes. In this study, a multi-PTM-omics approach, including proteome, ubiquitome, and phosphoproteome, was utilized to examine mechanisms of non-genomic AhR-signaling in endotoxin-activated monocyte-derived macrophages. This dataset entails proteome and phosphoproteome data.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Cell Culture, Macrophage
SUBMITTER: Henning Großkopf
LAB HEAD: Martin von Bergen
PROVIDER: PXD020770 | Pride | 2021-03-30
REPOSITORIES: Pride
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