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Loss of immunosuppressive and anti-inflammatory properties in transformed human mesenchymal stem cells

ABSTRACT: We used collection of sequentially mutated BM-hMSCs ranging from wild type (no oncogenic hits) to fully transformed hMSCs (targeted with up six oncogenic mutations)to address whether BM-hMSCs at different stages of a well-characterized oncogenic process (normal, immortalized, transformed) retain immunomodulatory properties in vitro and in vivo. We characterize, for the first time, an oncogenic transformation-associated loss of the immunesuppressive and anti-inflammatory properties by hMSCs and identify candidate immune effectors underlying the loss of immunomodulation in transformed hMSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55108 | GEO | 2015/05/14

SECONDARY ACCESSION(S): PRJNA238542

REPOSITORIES: GEO

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