Effect of SF3A1 inhibition on pre-mRNA splicing
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ABSTRACT: We previously found that the SF3A mRNA splicing complex was required for a robust innate immune response; SF3A acts in part by inhibiting the production of a negatively acting splice form of the TLR signaling adaptor MyD88. Here we inhibit SF3A1 using RNAi and subsequently perform an RNAseq study to identify the full complement of genes and splicing events regulated by SF3A in murine macrophages. Surprisingly, SF3A has substantial specificity for mRNA splicing events in innate immune signaling pathways compared to other pathways, affecting the splicing of many genes in the TLR signaling pathway to modulate the innate immune response.
ORGANISM(S): Mus musculus
PROVIDER: GSE58432 | GEO | 2015/02/09
SECONDARY ACCESSION(S): PRJNA252602
REPOSITORIES: GEO
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