Genome-wide Oct4 binding profile in lung cancer A549 cells
Ontology highlight
ABSTRACT: Oct4 stemness gene encoding a transcription factor has been shown to overexpress in cancers. However, precise mechanisms of Oct4 relevant to transcriptional reprogramming leading to somatic cancer progression remain unclear. To address the Oct4-mediated transcriptional program in lung cancer, we integrated genome-wide Oct4 binding profiles from chromatin-immunoprecipitation sequencing and ENCODE datasets. We identified that Oct4 occupied at functional promoter and enhancer regions of genes which play key roles in several signaling pathways involving tumorigenesis.
ORGANISM(S): Homo sapiens
PROVIDER: GSE58462 | GEO | 2015/02/04
SECONDARY ACCESSION(S): PRJNA253167
REPOSITORIES: GEO
ACCESS DATA