Regulation of tumor associated macrophages by cooperative inflammatory signaling
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ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE59047 | GEO | 2015/04/28
SECONDARY ACCESSION(S): PRJNA254208
REPOSITORIES: GEO
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Project description:Targeting the reprogramming and phagocytic capacities of tumor-associated macrophages (TAMs) has emerged as a therapeutic opportunity for cancer treatment. Here, we demonstrate that leukemic cell phagocytosis triggers the proinflammatory activation of TAMs as demonstrated by the upregulation and dowregulation of, respectively, proinflammatory and anti-inflammatory genes in phagocytic macrophages (Phago+) with respect to non-phagocytic macrophages (Phago-).
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