Transcriptomics

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Thrombospondin 1 in a model of colorectal carcinogenesis


ABSTRACT: By using a model of inflammation-induced carcinogenesis the effects of TSP-1 in induced tumors were analyzed. Mice received a single injection of azoxymethane (AOM) and multiple cycles of dextran sodium sulfate (DSS) for inducing chronic inflammation-related cancers. Proliferation and angiogenesis status were analyzed as well as their transcript profile by using a gene microarray approach. We used Affymetrix GeneChips to determine the changes in the genetic profile between WT and TSP-1 deficient tumors in a model of colorectal carcinogenesis. We identified differentially expressed genes between WT and TSP-1 deficient tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE60805 | GEO | 2015/08/26

SECONDARY ACCESSION(S): PRJNA259597

REPOSITORIES: GEO

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