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Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

ABSTRACT: Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs) and transit-amplifying cells (TACs). We used ChIP-seq to unfold genome-wide chromatin landscapes of H3K27ac and Med1 to identify super-enhancers and dissect their biological relevance in cell identity and plasticity of HFSCs in vivo and in vitro.

ORGANISM(S): Mus musculus

PROVIDER: GSE61316 | GEO | 2015/03/19

SECONDARY ACCESSION(S): PRJNA260731

REPOSITORIES: GEO

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