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Genome-wide profiling of the DNA methylation landscape at base-pair resolution in human acute myeloid leukemia cell lines.

ABSTRACT: Whole genome bisulphite sequencing of 2 human cancer cell line samples. One cell line harbours a heterozygous mutation in the DNA methyl-transferase DNMT3a, a common alteration observed in AML patients. The main goal is to find the differentially methylated regions (DMR) at genome-wide level between the mutant and a wild-type cell lines to elucidate the effect of the mutation and the implication in leukomogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62300 | GEO | 2015/10/07

SECONDARY ACCESSION(S): PRJNA263801

REPOSITORIES: GEO

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