Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

NUP98-HOXA9 role as oncogenic transcription factor

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62587 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA264476

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

NUP98-HOXA9 role as oncogenic transcription factor

Project description:NUP98-HOXA9 role as oncogenic transcription factor

| PRJNA264476 | ENA

Evaluation of the NUP98-HOXA9 role as oncogenic transcription factor

Project description:To study the oncogenic mechanism triggered by the leukemic fusion protein NUP98-HOXA9, we cloned the cDNA of NUP98-HOXA9 into a retroviral vector (pMSCV-IRES-GFP) and efficiently transduced the HEK293FT human cell line. We performed a ChIP-seq analysis to identify the DNA binding sites of NUP98-HOXA9. These results allowed us to demonstrate that NUP98-HOXA9 regulates the expression of genes involved in the development of Acute Myeloid Leukemia by directly interacting with their enhancer regions. We further investigated the functional contribution to the DNA binding profile of the two moieties that compose the fusion protein. We cloned the coding region of HOXA9 wt and NUP98 wt in the same retroviral vector, established two new cellular models, 293FT-HOXA9 and 293FT-NUP98, and performed separate ChIP-seq analyses. We demonstrated that both moieties contribute importantly to the regulation of the target genes.

2016-12-31 | GSE62586 | GEO

NUP98-PHF23

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-03-06 | E-GEOD-54788 | biostudies-arrayexpress

Role of EGR2 transcription factor in T cell anergy

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-21 | E-GEOD-46243 | biostudies-arrayexpress

A crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-12 | E-GEOD-52499 | biostudies-arrayexpress

JDP2 - an Oncogenic bZIP Transcription Factor in T-cell Acute Lymphoblastic Leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-18 | GSE115466 | GEO

Role of EGR2 transcription factor in T cell anergy

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-04-21 | GSE46243 | GEO

HMGA2/TET1/HOXA9 pathway regulates breast cancer growth and metastasis.

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-03 | E-GEOD-43741 | biostudies-arrayexpress

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle regulation to Drive Leukemic Transformation

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-12 | GSE117108 | GEO

NUP98-PHF23

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-03-06 | GSE54788 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data