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Gene expression profile on wt and mdx mice treated or untreated with Tadalafil

ABSTRACT: Microarray-based genomic analysis to assess the pattern of gene expression in muscle samples obtained from animals treated with tadalafil. This scrutiny allowed us to identify several classes of modulated genes that may provide hints for the identification of common factors underlying the improvement of muscle performance.

ORGANISM(S): Mus musculus

PROVIDER: GSE62639 | GEO | 2014/10/24

SECONDARY ACCESSION(S): PRJNA264612

REPOSITORIES: GEO

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Gene expression profile on wt and mdx mice treated or untreated with Tadalafil

Project description:Microarray-based genomic analysis to assess the pattern of gene expression in muscle samples obtained from animals treated with tadalafil. This scrutiny allowed us to identify several classes of modulated genes that may provide hints for the identification of common factors underlying the improvement of muscle performance. The pharmacological treatments were started before birth by oral administration and continued after birth until 16 weeks of age.

2014-10-24 | E-GEOD-62639 | biostudies-arrayexpress

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Project description:In this study, Pax7-Cre mediated inactivation of Sirt6 in mdx mice resulted in profound improvement of the mdx phenotype at the functional level. To study the underlying molecular mechanisms we performed RNA-seq of muscles from control, mdx and Sirt6mKO/mdx mice.

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Leg muscle mdx and control

Project description:Leg muscle mdx and control: 7,14,23 day Keywords: other

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