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Genetic analysis reveals a longevity associated protein modulating endothelial function and angiogenesis

ABSTRACT: Transcriptome analysis in HEK293T transfected with plasmid carrying different isoforms of BPIFB4 gene. This gene was previously associated with exceptional longevity in a GWAS study performed on three different populations. Results indicate an up-regulation of stress response genes and proteostasis genes in HEK293T transfected with plasmid carrying the longevity-associated variant (LAV) of BPIFB4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE63912 | GEO | 2015/06/12

SECONDARY ACCESSION(S): PRJNA269385

REPOSITORIES: GEO

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Genetic analysis reveals a longevity associated protein modulating endothelial function and angiogenesis

Project description:Transcriptome analysis in HEK293T transfected with plasmid carrying different isoforms of BPIFB4 gene. This gene was previously associated with exceptional longevity in a GWAS study performed on three different populations. Results indicate an up-regulation of stress response genes and proteostasis genes in HEK293T transfected with plasmid carrying the longevity-associated variant (LAV) of BPIFB4. Total RNA obtained from HEK293T over-expressing wild-type or mutated form of BPIFB4.

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