Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from hsr containing human embryonic stem cell line, H14, and parent H14 human embryonic stem cell line.

ABSTRACT: Homogenous staining regions (hsr) are cytogenetic representations of a gene amplification. They are found exclusively in tumour cells. We found a hsr in the human embryonic stem cell (hESC) line H14, this is the first report of a hsr in hESCs. FISH and CGH studies showed that the hsr was derived from chromosome 17p11.2. The gene expression analysis studies were performed to identify the genes upregulated due to the hsr by comparison the the hsr-contianing H14 cells with a karyotypically normal parent H14 cell line. Keywords: karyotypically abnormal hESC vs karyotypically normal hESC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE6561 | GEO | 2007/02/10

SECONDARY ACCESSION(S): PRJNA98779

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling of human embryonic stem cell line containining HSR H14, and parent H14 l

Project description:Homogenous staining regions (hsr) are cytogenetic representations of a gene amplification. They are found exclusively in tumour cells. We found a hsr in the human embryonic stem cell (hESC) line H14, this is the first report of a hsr in hESCs. FISH and CGH studies showed that the hsr was derived from chromosome 17p11.2. The gene expression analysis studies were performed to identify the genes upregulated due to the hsr by comparison the the hsr-contianing H14 cells with a karyotypically normal parent H14 cell line. Experiment Overall Design: H14 HSR positive embryonic stem cells and H14 HSR negative cells were hybridised to Affymetrix U133 Plus 2.0 expression arrays. Replicates were also run using H14 positive and H14 negative cells from different passages.

2008-06-14 | E-GEOD-6561 | biostudies-arrayexpress

Halanaeroarchaeum sp. HSR-CO

Project description:Halanaeroarchaeum sp HSR-CO Genome sequencing

| PRJNA752267 | ENA

Coturnix coturnix strain:HSR

Project description:Coturnix coturnix strain:HSR Genome sequencing

| PRJNA261665 | ENA

Impact of DNA demethylation agents (5-azacytidine or vitamin C) on gene expression in glioblastoma HSR-GBM1 cells

Project description:Glioblastoma HSR-GBM1 cells have low mitochondrial DNA copy numbers which is associated with the abnormal DNA methylation patterns. By inducing DNA demthylation using 5azacytidine and vitamin C, HSR-GBM1 cells modulate their mitochondrial copy number and capability of differentiation.

2018-12-26 | GSE98692 | GEO

Impact of DNA demethylation agents (5-azacitidine or vitamin C) on DNA copy number in gliobalstoma HSR-GBM1 cells

Project description:Glioblastoma HSR-GBM1 cells have low mitochondrial DNA copy numbers which is associated with the abnormal DNA methylation patterns. By inducing DNA demthylation using 5azacitidine and vitamin C, HSR-GBM1 cells modulate their mitochondrial copy number and capability of diffrentiation.

2018-12-26 | GSE98377 | GEO

Brucella abortus strain:-ABT/CB-28/2016/HSR

Project description:Brucella abortus strain:-ABT/CB-28/2016/HSR Genome sequencing and assembly

| PRJNA643995 | ENA

OGA-mediated protein glycosylation regulates pluripotency states in human embryonic stem cells

Project description:In our previous study, we uncovered that OGA significantly elevated in naïve hESC. Therefore, we sought to investigate the effects of O-GlcNAc on hESC and the interconvert of both pluripotent states. Depletion of OGA, which results in global O-GlcNAcylation increased, would impair naïve hESC pluripotency but can promote naïve to primed hESC transition. In addition, we obtained the profiles of O-GlcNAcylated proteins in H9 primed hESC and H9-PXGL hESC via MS based-quantitative proteomics.

2024-08-10 | PXD041605 | Pride

Pasteurella multocida subsp. multocida strain:ABT/RAWAL/2015/HSR

Project description:Pasteurella multocida subsp. multocida strain:ABT/RAWAL/2015/HSR Genome sequencing and assembly

| PRJNA644349 | ENA

Homo sapiens

Project description:Expression data from hsr containing human embryonic stem cell line, H14, and parent H14 human embryonic stem cell line.

| PRJNA98779 | ENA

Pharmacogenetic profiling of human embryonic stem cells

Project description:Predicting response to drug or xenobiotic exposure is vital to risk assessment and clinical response rates. Primary human hepatocytes are commonly used to evaluate liver drug metabolism and toxicity. They are the most physiologically relevant in vitro model, retaining expression of most ADME-relevant genes. However, human hepatocytes are source limited, have high donor variability, only survive short term in culture, and lack selection for specific genetic profiles. To overcome the limitations associated with primary hepatocytes we and others are investigating the potential of pluripotent stem cells as an alternative or complementary source for generating hepatocytes. Pluripotent stem cells offer advantages over primary hepatocytes because stem cells have high replicative capacity, potentially providing a limitless source of hepatocytes. Stem cell derived hepatocytes (SCDHs) may also provide an improved in vitro system for evaluating pharmacogenetic relationships, e.g. cytochrome P450 (CYP) enzymes and their impact on drug metabolism and toxicity. To demonstrate the utility of SCDHs in pharmacogenetic screening, we genotyped the five commonly used WiCell® human embryonic stem cell lines (hESC), H1, H7, H9, H13 and H14.

2016-05-24 | GSE53889 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data