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Targeting Jak2-Stat5a/b signaling suppresses growth of enzalutamide-resistant prostate cancer in vitro and in vivo

ABSTRACT: We used cDNA microarray analysis to identify the Stat5a/b transcriptome in AR-depleted CWR22Pc cells. We sequentially depleted AR protein (AR knockdown) followed by Stat5a/b (Stat5a/b knockdown) using lentiviral shRNA in CWR22Pc cells. CWR22Pc cells were transduced with scramble shRNA (shCtrl), shAR or shStat5a/b at the start of the experiment (day 0), followed by transduction with a second lentiviral shRNA, either shCtrl or shStat5a/b, 3 days later (day 3). CWR22Pc cells were harvested on day 6 for analysis of gene expression profiles.

ORGANISM(S): Homo sapiens

PROVIDER: GSE68993 | GEO | 2016/05/01

SECONDARY ACCESSION(S): PRJNA284283

REPOSITORIES: GEO

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