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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE70160 | GEO | 2015/08/06

SECONDARY ACCESSION(S): PRJNA287760

REPOSITORIES: GEO

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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [microarray]

Project description:Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice.

2015-08-06 | GSE71716 | GEO

Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-? and IL-6 Immune Response Pathways in Mice.

Project description:Selenium is an essential element that is required to support a number of cellular functions and biochemical pathways. The objective of this study was to examine the effects of reduced dietary selenium levels on gene expression to assess changes in expression of non-selenoprotein genes that may contribute to the physiological consequences of selenium deficiency. Mice were fed diets that were either deficient in selenium or supplemented with selenium in the form of sodium selenite for six weeks. Differences in liver mRNA expression and translation were measured using a combination of ribosome profiling, RNA-Seq, microarrays, and qPCR. Expression levels and translation of mRNAs encoding stress-related selenoproteins were shown to be up-regulated by increased selenium status, as were genes involved in inflammation and response to interferon-?. Changes in serum cytokine levels were measured which confirmed that interferon-?, as well as IL-6, were increased in selenium adequate mice. Finally, microarray and qPCR analysis of lung tissue demonstrated that the selenium effects on immune function are not limited to liver. These data are consistent with previous reports indicating that adequate selenium levels can support beneficial immune responses, and further identify the IL-6 and interferon-? pathways as being responsive to dietary selenium intake.

| S-EPMC4555136 | biostudies-literature

Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [RNA-Seq]

2015-08-06 | E-GEOD-70158 | biostudies-arrayexpress

Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [Ribosome Profiling]

2015-08-06 | E-GEOD-70159 | biostudies-arrayexpress

Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [Ribosome Profiling]

2015-08-06 | GSE70159 | GEO

Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [RNA-Seq]

2015-08-06 | GSE70158 | GEO

Dietary selenium levels affect selenoprotein expression and support the interferon-? and IL-6 immune response pathways in mice [microarray]

2015-08-06 | E-GEOD-71716 | biostudies-arrayexpress

Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes.

Project description:Background:Selenium is an essential trace element and is suggested to play a role in the etiology of a number of chronic diseases. Genetic variation in genes encoding selenoproteins, such as selenoprotein P and the glutathione peroxidases, may affect selenium status and, thus, individual susceptibility to some chronic diseases. In the present study, we aimed to (1) investigate the effect of mussel and fish intake on glutathione peroxidase enzyme activity and (2) examine whether single nucleotide polymorphisms in the GPX1, GPX4, and SELENOP genes modify the effect of mussel and fish intake for 26 weeks on whole blood selenium, plasma selenoprotein P concentrations, and erythrocyte GPX enzyme activity in a randomized intervention trial in Denmark. Results:CC homozygotes of the SELENOP/rs3877899 polymorphism who consumed 1000 g fish and mussels per week for 26 consecutive weeks had higher levels of both selenoprotein P (difference between means -?4.68 ng/mL (95% CI -?8.49, -?0.871)) and whole blood selenium (difference between means -?5.76 (95% CI -?12.5, 1.01)) compared to fish and mussel consuming T-allele carriers although the effect in whole blood selenium concentration was not statistically significant. Conclusions:Our study indicates that genetically determined variation in SELENOP leads to different responses in expression of selenoproteins following consumption of selenium-rich foods. This study also emphasizes the importance of taking individual aspects such as genotypes into consideration when assessing risk in public health recommendations.

| S-EPMC6045871 | biostudies-literature

The effects of dietary selenium on selenocysteine incorporation and selenoprotein expression

Project description:The goal of this study was to determine the effects of dietary selenium levels on translational control of selenoprotein synthesis in mouse liver.

2013-09-17 | GSE46038 | GEO

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα.

Project description:Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a controlled hepatocarcinogenesis study involving varying levels of dietary selenium and altered selenoprotein status using mice carrying a mutant (A37G) selenocysteine tRNA transgene (Trsp(tG37) ) and/or a cancer driver TGFα transgene. The use of Trsp(tG37) altered selenoprotein expression in a selenoprotein and tissue specific manner and, at sufficient dietary selenium levels, separate the effect of diet and selenoprotein status. Mice were maintained on diets deficient in selenium (0.02 ppm selenium) or supplemented with 0.1, 0.4 or 2.25 ppm selenium or 30 ppm triphenylselenonium chloride (TPSC), a non-metabolized selenium compound. Trsp(tG37) transgenic and TGFα/Trsp(tG37) bi-transgenic mice subjected to selenium-deficient or TPSC diets developed a neurological phenotype associated with early morbidity and mortality prior to hepatocarcinoma development. Pathology analyses revealed widespread disseminated pyogranulomatous inflammation. Pyogranulomas occurred in liver, lungs, heart, spleen, small and large intestine, and mesenteric lymph nodes in these transgenic and bi-transgenic mice. The incidence of liver tumors was significantly increased in mice carrying the TGFα transgene, while dietary selenium and selenoprotein status did not affect tumor number and multiplicity. However, adenoma and carcinoma size and area were smaller in TGFα transgenic mice that were fed 0.4 and 2.25 versus 0.1 ppm of selenium. Thus, selenium and selenoprotein deficiencies led to widespread pyogranuloma formation, while high selenium levels inhibited the size of TGFα-induced liver tumors.

| S-EPMC3583866 | biostudies-literature

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