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Nurr1 and Retinoid X Receptor ligands stimulate Ret signaling in dopamine neurons and can alleviate α-synuclein disrupted gene expression

ABSTRACT: We ovexpressed human alpha synuclein alone or together with Nurr1 in mouse primary midbrain cultures and identified the full spectrum of genes whose expression is affected by alpha synuclein, including genes whose expression is normalized after Nurr1 overexpression. Moreover we treated mouse primary midbrain cultures with Bexarotene or short hairpin RNA fro Nurr1, sorted out the dopamine neurons and assessed the effects of Bexarotene and of the Nurr1 downregulation on gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE70368 | GEO | 2015/07/15

SECONDARY ACCESSION(S): PRJNA288457

REPOSITORIES: GEO

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Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

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