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Expression data from Rat lungs

ABSTRACT: We sought to confirm the genetic influence in the development of Ventilation-Associated Lung Injury (VALI) and, in the process, identify potential candidate genes involved in the disease by integrating differential gene expression profiling on rat lungs to a traditional strain survey analysis of the parental rat strains, VALI-sensitive Brown Norway rats versus VALI-resistant Dahl Salt Sensitive rats, comparing control (under room air ventilation) versus under high tidal volume (HTV) ventilation. We used microarrays to detail the global programme of gene expression underlying VALI susceptibility and identified distinct classes of up-regulated and down-regulated genes during this process. Keywords: strain-condition analysis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE7041 | GEO | 2007/02/15

SECONDARY ACCESSION(S): PRJNA98503

REPOSITORIES: GEO

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