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Expression data from human primary skeletal muscle myotubes treated with aldosterone, spironolactone, or vehicle.

ABSTRACT: To test for a function effect of mineralocorticoid receptor modulation in skeletal muscle, global gene expression analysis was conducted on human myltubes treated with a mineralocorticoid receptor agonist or antagonist.

ORGANISM(S): Homo sapiens

PROVIDER: GSE70822 | GEO | 2015/07/14

SECONDARY ACCESSION(S): PRJNA289645

REPOSITORIES: GEO

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Expression data from human primary skeletal muscle myotubes treated with aldosterone, spironolactone, or vehicle.

Project description:To test for a function effect of mineralocorticoid receptor modulation in skeletal muscle, global gene expression analysis was conducted on human myltubes treated with a mineralocorticoid receptor agonist or antagonist. 9 total samples were analyzed. 3 biological replicates for each of the following treatment groups were included: 1) aldosterone; 2) spironolactone; 3) vehicle (ethanol). Pairwise comparison between groups were carried out and a fold-change ≥2 were selected.

2015-07-14 | E-GEOD-70822 | biostudies-arrayexpress

Expression data from human primary skeletal muscle myotubes treated with aldosterone, spironolactone, eplerenone, mifepristone, prednisolone or vehicle

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Expression data from human primary skeletal muscle myotubes treated with aldosterone alone or co-incubated with aldosterone plus spironolactone, eplerenone, or mifepristone

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Differential antagonistic effects of finerenone and spironolactone on the aldosterone transcriptome in human kidney cells.

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Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR-gamma activation

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