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Gene expression profiling of SHSY5Y cells exposed to manganese

ABSTRACT: The trace element manganese is essential for normal development for all the organisms. Overexposure of manganese may leads to multiple neuronal disorders such as Parkinson, manganism. To explore the molecular mechanism of manganese induced neurotoxicity, gene expression profiling was performed on human neuroblastoma SHSY-5Y cells. Cells were exposed to sub-lethal concentration of manganese (100 μM) for 24 hrs. Our result demonstrates that manganese alter multiple biological pathways including chromatin assembly, neurogenesis and apoptotic pathways.Cells grown in 75mm2 flask. three replicates for each sample

ORGANISM(S): Homo sapiens

PROVIDER: GSE70845 | GEO | 2016/07/01

SECONDARY ACCESSION(S): PRJNA289673

REPOSITORIES: GEO

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Gene expression profiling of SHSY5Y cells exposed to manganese

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