Transcriptomics

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Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress


ABSTRACT: Mdr2 is the transporter of phosphatidylcholine, which is an essential component of bile. Deficiency of mdr2 causes hepatic inflammation, liver fibrosis and hepatocellular carcinoma. Mdr2-/- MEFs show increased proliferation, spontaneous transformation and tumorigenesis. We used microarray to obtain genome-wide profiling of gene expression underlying the changes in mdr2-/- MEFs.

ORGANISM(S): Mus musculus

PROVIDER: GSE72615 | GEO | 2015/09/02

SECONDARY ACCESSION(S): PRJNA294459

REPOSITORIES: GEO

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