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Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism

ABSTRACT: We report the genome-wide localization of SESAME and found that three SESAME subunits localized in the gene body.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE72972 | GEO | 2015/11/04

SECONDARY ACCESSION(S): PRJNA295966

REPOSITORIES: GEO

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Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism

Project description:We report the genome-wide localization of SESAME and found that three SESAME subunits localized in the gene body. Examining the genome-wide localization of SESAME subunits (Sam1, Ser33, Pyk1) and Set1

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Next Generation Sequencing Analysis of Wild Type and SESAME Transcriptomes II

Project description:The purpose is to analyze the effect of SESAME complex on gene transcription

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Next Generation Sequencing Analysis of Wild Type and SESAME Transcriptomes I

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Project description:Telomeres are organized into a heterochromatin structure and maintenance of silent heterochromatin is required for chromosome stability. How telomere heterochromatin is dynamically regulated in response to stimuli remains unknown. Pyruvate kinase Pyk1 forms a complex, named SESAME (Serine-responsive SAM-containing Metabolic Enzyme complex) to regulate gene expression by phosphorylating histone H3T11 (H3pT11). Here, we identified a novel function of SESAME in regulating telomere heterochromatin structure. SESAME phosphorylates H3T11 at telomeres, which promotes SIR (silent information regulator) complex assembly at telomeres and protects Sir2 from degradation by autophagy. Moreover, SESAMEcatalyzed H3pT11 directly represses autophagy-related gene expression to further prevent autophagy-mediated Sir2 degradation. By promoting H3pT11, serine increases Sir2 protein levels and enhances telomere silencing. Loss of H3pT11 leads to reduced Sir2 and compromised telomere silencing during chronological aging. Together, our study provides insights into dynamic regulation of silent heterochromatin by histone modifications and autophagy in response to cell metabolism and aging.

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