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Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism

ABSTRACT: We report the genome-wide localization of SESAME and found that three SESAME subunits localized in the gene body.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE72972 | GEO | 2015/11/04

SECONDARY ACCESSION(S): PRJNA295966

REPOSITORIES: GEO

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Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism

Project description:We report the genome-wide localization of SESAME and found that three SESAME subunits localized in the gene body. Examining the genome-wide localization of SESAME subunits (Sam1, Ser33, Pyk1) and Set1

2015-11-04 | E-GEOD-72972 | biostudies-arrayexpress

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RNA-seq in Black and White Sesame

Project description:Sesame seeds is an important traditional crop with high oil content and other abundant nutrients which are very beneficial for diet and health of human being. However, the molecular mechanism for metabolite accumulation, especially for oil and phenylpropanoid biosynthesis, is still not very clear in sesame. In this study, the transcriptome profiles of black and white sesame seeds were compared by RNA-sequencing. Transcriptome analysis showed that the expression patterns of genes encoding phenylpropanoid pathway enzymes were different between the two sesame cultivars. Compared with white sesame, most of genes involved in oil biosynthesis were significantly down-regulated in black sesame.

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Project description:The genome sequences of 715 sesame varieties

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Next Generation Sequencing Analysis of Wild Type and SESAME Transcriptomes II

Project description:The purpose is to analyze the effect of SESAME complex on gene transcription

2021-03-25 | GSE147764 | GEO

Next Generation Sequencing Analysis of Wild Type and SESAME Transcriptomes I

Project description:The purpose is to analyze the effect of SESAME complex on gene transcription

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Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation

Project description:Telomeres are organized into a heterochromatin structure and maintenance of silent heterochromatin is required for chromosome stability. How telomere heterochromatin is dynamically regulated in response to stimuli remains unknown. Pyruvate kinase Pyk1 forms a complex, named SESAME (Serine-responsive SAM-containing Metabolic Enzyme complex) to regulate gene expression by phosphorylating histone H3T11 (H3pT11). Here, we identified a novel function of SESAME in regulating telomere heterochromatin structure. SESAME phosphorylates H3T11 at telomeres, which promotes SIR (silent information regulator) complex assembly at telomeres and protects Sir2 from degradation by autophagy. Moreover, SESAMEcatalyzed H3pT11 directly represses autophagy-related gene expression to further prevent autophagy-mediated Sir2 degradation. By promoting H3pT11, serine increases Sir2 protein levels and enhances telomere silencing. Loss of H3pT11 leads to reduced Sir2 and compromised telomere silencing during chronological aging. Together, our study provides insights into dynamic regulation of silent heterochromatin by histone modifications and autophagy in response to cell metabolism and aging.

2020-12-04 | GSE147050 | GEO

RNA-Sequencing of PEG-stressed Sesame roots in drought sensitive and tolerant genotypes

Project description:Purpose: The goals of this study are to understand transcriptional changes in the roots of drought-tolerant and sensitive sesame genotypes using PEG (Polyethylene glycol) induced osmotic stress.

2020-07-02 | GSE148340 | GEO

Bulk segregant RNA seq samples from young leaf tissue of sesame seedlings with either SiCD-A or SiCD-B allele

Project description:Transcriptome analysis was performed on young leaves from 17-day old sesame seedling. The experiment aimed to shed light on the polar regulatory gene network in sesame under KANADI1 loss of function and identify candidate genes underlie the hyponastic leaf phenotype. We compaired between homozygous lines for either SiCD-A allele contains KAN1 (WT) or SiCD-B allele contains kan1 (mutant) on S.indicum LG8.

2022-01-10 | GSE164511 | GEO

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