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TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses

ABSTRACT: The RNA-seq results reveal TMPyP4 and TPyP4 could promote cancer cell migration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72983 | GEO | 2015/09/14

SECONDARY ACCESSION(S): PRJNA295536

REPOSITORIES: GEO

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TMPyP4 promotes cancer cell migration at low dose, but induces cell death at high dose

Project description:The RNA-seq results reveal TMPyP4 and TPyP4 could promote cancer cell migration. Examination of the gene expression of the following cells:A549-untreated and TMPyP4-treated or TPyP4-treated.

2015-09-14 | E-GEOD-72983 | biostudies-arrayexpress

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses.

Project description:TMPyP4 is widely considered as a potential photosensitizer in photodynamic therapy and a G-quadruplex stabilizer for telomerase-based cancer therapeutics. However, its biological effects including a possible adverse-effect are poorly understood. In this study, whole genome RNA-seq analysis was used to explore the alteration in gene expression induced by TMPyP4. Unexpectedly, we find that 27.67% of changed genes were functionally related to cell adhesion. Experimental evidences from cell adhesion assay, scratch-wound and transwell assay indicate that TMPyP4 at conventional doses (?0.5??M) increases cell-matrix adhesion and promotes the migration of tumor cells. In contrast, a high dose of TMPyP4 (?2??M) inhibits cell proliferation and induces cell death. The unintended "side-effect" of TMPyP4 on promoting cell migration suggests that a relative high dose of TMPyP4 is preferred for therapeutic purpose. These findings contribute to better understanding of biological effects induced by TMPyP4 and provide a new insight into the complexity and implication for TMPyP4 based cancer therapy.

| S-EPMC4879555 | biostudies-literature

Telomerase inhibitor TMPyP4 induced gene expression

Project description:The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course Cells were treated with TMPyP4 for either 24 or 48 hours before RNA isolation.Untreated cells were taken as controls and the TMPyP4 treated cells as treatments. Experiments at each time point were replicated four times.

2010-06-10 | E-GEOD-5226 | biostudies-arrayexpress

Telomerase inhibitor TMPyP4 induced widespread gene expression

Project description:The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes, analyzed across different cell-lines, was investigated Keywords: Comparative gene-expression profiling Cells were treated with TMPyP4 for 48 hours before RNA isolation. Untreated cells were taken as controls and the TMPyP4 treated cells as treatments. Experiments in each cell-line (A549 and HeLa S3) were replicated four times.

2010-06-20 | E-GEOD-9710 | biostudies-arrayexpress

Telomerase inhibitor TMPyP4 induced gene expression

Project description:The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course

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Telomerase inhibitor TMPyP4 induced widespread gene expression

2008-08-25 | GSE9710 | GEO

The effect of G-quadruplex on gene expression by treating S2 cell with different concentration of TMPyP4

Project description:In this study, G-quadruplex ligand TMPyP4 was utilized to treat S2 cell and DMSO was served as control. The stabilization role of TMPyP4 will promote the formation of G-quadruplex and then affect gene expression. Identifying whether the effect is positive or negative is important for our understanding of the functionality of non-coding element.

2024-05-13 | GSE131691 | GEO

High-throughout sequencing of ovarian cancer cells treated with TMPyP4 and H2O2

Project description:The high-throughput sequencing technology was performed after the treatment of human ovarian cancer cells A2780 with TMPyP4 and H2O2 purchased from Sigma-Aldrich, to explore the expression of genes related to cell proliferation, DNA damage and ROS levels of ovarian cancer cells A2780 after the treatment of TMPyP4 and H2O2, and to find an interesting target pathway,HIF-1 signaling pathway.

2024-03-25 | GSE262015 | GEO

DNA microarray analysis in hippocampus of Wild-type (WT), AtrxΔE2, and TMPyP4-treated AtrxΔE2 mice.

Project description:TMPyP4 treatment antagonizes cognitive deficits seen in ATR-X model (AtrxΔE2) mice. Our findings suggest a potential therapeutic strategy to target G-quadruplexes and decrease cognitive impairment associated with ATR-X syndrome.

2018-01-28 | GSE103032 | GEO

FSTL1 promotes keratinocyte migration.

Project description:This study identifies FSTL1 as key component of intiating keratinocyte migration in skin Total RNA from N/TERT-1 keratinocytes transfected with a non-targeting siRNA or Smartpool siRNA against FSTL1 were subjected to microarray analysis

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