Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA microarray analysis in hippocampus of Wild-type (WT), AtrxΔE2, and TMPyP4-treated AtrxΔE2 mice.

ABSTRACT: TMPyP4 treatment antagonizes cognitive deficits seen in ATR-X model (AtrxΔE2) mice. Our findings suggest a potential therapeutic strategy to target G-quadruplexes and decrease cognitive impairment associated with ATR-X syndrome.

ORGANISM(S): Mus musculus

PROVIDER: GSE103032 | GEO | 2018/01/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

DNA microarray analysis in hippocampus of Wild-type (WT), AtrxΔE2, and 5-aminolevulinic acid (5-ALA) treated AtrxΔE2 mice.

Project description:5-ALA that can be metabolized to porphyrins, protoporphyrin IX and hemin antagonizes decreased synaptic plasticity and cognitive deficits seen in ATR-X model (AtrxΔE2) mice. Our findings suggest a potential therapeutic strategy to target G-quadruplexes and decrease cognitive impairment associated with ATR-X syndrome.

2018-01-28 | GSE103031 | GEO

Telomerase inhibitor TMPyP4 induced gene expression

Project description:The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course Cells were treated with TMPyP4 for either 24 or 48 hours before RNA isolation.Untreated cells were taken as controls and the TMPyP4 treated cells as treatments. Experiments at each time point were replicated four times.

2010-06-10 | E-GEOD-5226 | biostudies-arrayexpress

Telomerase inhibitor TMPyP4 induced widespread gene expression

Project description:The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes, analyzed across different cell-lines, was investigated Keywords: Comparative gene-expression profiling Cells were treated with TMPyP4 for 48 hours before RNA isolation. Untreated cells were taken as controls and the TMPyP4 treated cells as treatments. Experiments in each cell-line (A549 and HeLa S3) were replicated four times.

2010-06-20 | E-GEOD-9710 | biostudies-arrayexpress

Telomerase inhibitor TMPyP4 induced gene expression

Project description:The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course

2007-06-20 | GSE5226 | GEO

Telomerase inhibitor TMPyP4 induced widespread gene expression

2008-08-25 | GSE9710 | GEO

TMPyP4 promotes cancer cell migration at low dose, but induces cell death at high dose

Project description:The RNA-seq results reveal TMPyP4 and TPyP4 could promote cancer cell migration. Examination of the gene expression of the following cells:A549-untreated and TMPyP4-treated or TPyP4-treated.

2015-09-14 | E-GEOD-72983 | biostudies-arrayexpress

High-throughout sequencing of ovarian cancer cells treated with TMPyP4 and H2O2

Project description:The high-throughput sequencing technology was performed after the treatment of human ovarian cancer cells A2780 with TMPyP4 and H2O2 purchased from Sigma-Aldrich, to explore the expression of genes related to cell proliferation, DNA damage and ROS levels of ovarian cancer cells A2780 after the treatment of TMPyP4 and H2O2, and to find an interesting target pathway,HIF-1 signaling pathway.

2024-03-25 | GSE262015 | GEO

RNA-Seq in hippocampus of control and Jade2-KO mice

Project description:Impairment of synaptic plasticity is involved in a range of pathological conditions such as cognitive deficits. However, how synaptic efficacy is regulated is not fully understood. Here, we report that the epigenetic factor Jade family PHD finger 2 (JADE2), which is upregulated by neuronal activities, is critically involved in the maintenance of hippocampal synaptic plasticity and cognitive functions in mice. Knockdown or genetic deletion of JADE2 in hippocampal CA1 results in impaired structural and functional synaptic plasticity, leading to memory impairment, whereas overexpression of JADE2 in CA1 neurons facilitates hippocampal-dependent learning and memory. Mechanistically, we show that JADE2 modulates synaptic functions mainly by transcriptional activation of cytoskeletal protein RAC1, and this activity is dependent on its interaction with histone acetyltransferase HBO1. Together, our findings suggest JADE2 is a critical player for experience-dependent gene regulation in controlling synaptic plasticity and cognitive functions.

2022-04-11 | GSE197460 | GEO

Single Cell RNAseq of the hippocampus after RSD following microglia depletion

Project description:Chronic stress is associated with anxiety and cognitive impairment. Repeated social defeat (RSD) in mice induces anxiety-like behavior driven by microglia and the recruitment of inflammatory monocytes to the brain. Nonetheless, it is unclear how microglia communicate with other cells to modulate the physiological and behavioral responses to stress. Using single-cell (sc)RNAseq, novel stress-associated microglia were identified in the hippocampus and defined by RNA profiles of cytokine/chemokine signaling, cellular stress, and phagocytosis. Microglia depletion with a CSF1R antagonist (PLX5622) attenuated the stress-associated profile of leukocytes, endothelia, and astrocytes. Furthermore, RSD-induced social withdrawal and cognitive impairment were microglia dependent, but social avoidance was microglia independent. Furthermore, single-nuclei (sn)RNAseq showed robust responses to RSD in hippocampal neurons that were both microglia dependent and independent. Notably, stress-induced CREB, oxytocin, and glutamatergic signaling in neurons were microglia dependent. Collectively, these stress-associated microglia influenced transcriptional profiles in the hippocampus linked to social and cognitive deficits.

2024-10-02 | GSE275205 | GEO

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses

Project description:The RNA-seq results reveal TMPyP4 and TPyP4 could promote cancer cell migration.

2015-09-14 | GSE72983 | GEO