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Gene Regulation by microRNA-16 forced expression in ErbB-2 positive murine breast cancer cells.

ABSTRACT: miR-16 is a potent tumor suppressor in ErbB-2 positive breast cancer. The primary objetive of this study was to identify previously uncharacterized putative mRNA targets of miR-16 in ErbB-2 postitive breast cancer cells. To achieve our objective we studied the effects of exogenously expressed miR-16 on the gene expression profile of primary cultures of ErbB-2 positive murine breast cancer tumors. The C4HD tumor line displays high levels of estrogen receptor and progesterone receptor, overexpresses ErbB-2 and ErbB-3, exhibits low ErbB-4 levels, and lacks EGF-R expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE73900 | GEO | 2016/05/04

SECONDARY ACCESSION(S): PRJNA298360

REPOSITORIES: GEO

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