Genomics

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In vitro microRNA screening in human pancreatic adenocarcinoma


ABSTRACT: No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma. MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas. This study assesses chemoresistant PDAC for its specific miR expression pattern. Gemcitabine-resistant variants of PANC-1, a mutant p53 human pancreatic adenocarcinoma cell line, were established. MicroRNA screening was investigated by microarray.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE74562 | GEO | 2015/11/03

SECONDARY ACCESSION(S): PRJNA300842

REPOSITORIES: GEO

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