Comparative analysis of gene expression in HAT4-nulls and HAT2-heterozygous knockout cells, versus wild type Leishmania donovani cells

ABSTRACT: Histone acetylations are known to impact gene transcription. Here, we have attempted to examine the role of Leishmania donovani histone acetyltransferases HAT4 and HAT2 in regulating global gene expression. The transcriptome of HAT4-null promastigotes (Samples 2A, 2B) and HAT2-heterozygous knockout promastigotes (Samples 3A, 3B) have been compared with the transcriptome of wild-type Leishmania promastigotes (Samples 1A, 1B) and fold change in gene expression with respect to the control wild-type has been determined.

ORGANISM(S): Leishmania donovani

PROVIDER: GSE76574 | GEO | 2016/07/31

SECONDARY ACCESSION(S): PRJNA308075

REPOSITORIES: GEO