Methylation profiling

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DNA methylation changes induced by overexpression of IDH1mut or treatment with 2HG in the sorted mouse bone marrow cells


ABSTRACT: Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene expression, and thus may promote tumorigenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE77828 | GEO | 2016/06/01

SECONDARY ACCESSION(S): PRJNA311700

REPOSITORIES: GEO

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